AIC Seminar Series

Proteome Analyst (PA) is a publicly available, high-throughput, web-based system for predicting various properties of each protein in an entire proteome. Using machine-learned classifiers, PA can predict, for example, the GeneQuiz general function and Gene Ontology (GO) molecular function of a protein. In addition, PA is one of the most accurate and most comprehensive systems for predicting subcellular localization, the location within a cell where a protein performs its main function. Two other capabilities of PA are notable. First, PA can create a custom classifier to predict a new property, without requiring any programming, based on labeled training data (i.e. a set of examples, each with the correct classification label) provided by a user. PA has been used to create custom classifiers for potassium-ion channel proteins and other general function ontologies. Second, PA provides a sophisticated explanation feature that shows why one prediction is chosen over another. The PA system produces a Naive Bayes classifier, which is amenable to a graphical and interactive approach to explanations for its predictions; transparent predictions increase the user’s confidence in, and understanding of, PA.

Please arrive at least 10 minutes early in order to sign in and be escorted to the conference room. SRI is located at 333 Ravenswood Avenue in Menlo Park. Visitors may park in the visitors lot in front of Building E, and should follow the instructions by the lobby phone to be escorted to the meeting room. Detailed directions to SRI, as well as maps, are available from the Visiting AIC web page.

©2013 SRI International 333 Ravenswood Avenue, Menlo Park, CA 94025-3493
SRI International is an independent, nonprofit corporation. Privacy policy