AIC Seminar Series
Using Evolutionary Modeling to Help Uncover Genetic Factors in Human Disease
| Paul D Thomas | Aritificial Intelligence Center, SRI International | |
Date: Thursday August 30, 2007 at 16:00
Location: EJ228 (SRI E building) (Directions)
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I will discuss the application of evolutionary modeling to the problem of predicting which genetic polymorphisms are most likely to impact phenotype. The evolutionary history of a gene, as well as the histories of related genes, provides information about the sequence changes that have been the target of natural selection. My group has used measures of both negative selection (evolutionary conservation) and positive selection across different species to help predict the effects of genetic mutations and polymorphisms in the human population.
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