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AIC Seminar Series

Using Evolutionary Modeling to Help Uncover Genetic Factors in Human Disease

Paul D ThomasAritificial Intelligence Center, SRI International

Date:  2007-08-30 at 16:00

Location:  EJ228 (SRI E building)  (Directions)

   Abstract

I will discuss the application of evolutionary modeling to the problem of predicting which genetic polymorphisms are most likely to impact phenotype. The evolutionary history of a gene, as well as the histories of related genes, provides information about the sequence changes that have been the target of natural selection. My group has used measures of both negative selection (evolutionary conservation) and positive selection across different species to help predict the effects of genetic mutations and polymorphisms in the human population.

   Bio for Paul D Thomas

Evolutionary Systems Biology Group page

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