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Publication Details

EcoCyc: a comprehensive view of Escherichia coli biology

by Keseler, I.M. and Bonavides-Martinez, C. and Collado-Vides, J. and Gama-Castro, S. and Gunsalus, R.P. and Johnson, D.A. and Krummenacker, M., and Nolan, L.M. and Paley, S. and Paulsen, I.T. and Peralta-Gil, M. and Santos-Zavaleta, A. and Shearer, A.G. and Karp, P.D.

Nucleic Acids Research, vol. 37, pp. D464-D470, Jan 2009.

Abstract

EcoCyc (http://EcoCyc.org) provides a comprehensive encyclopedia of Escherichia coli biology. EcoCyc integrates information about the genome, genes and gene products; the metabolic network; and the regulatory network of E. coli. Recent EcoCyc developments include a new initiative to represent and curate all types of E. coli regulatory processes such as attenuation and regulation by small RNAs. EcoCyc has started to curate Gene Ontology (GO) terms for E. coli and has made a dataset of E. coli GO terms available through the GO Web site. The curation and visualization of electron transfer processes has been significantly improved. Other software and Web site enhancements include the addition of tracks to the EcoCyc genome browser, in particular a type of track designed for the display of ChIP-chip datasets, and the development of a comparative genome browser. A new Genome Omics Viewer enables users to paint omics datasets onto the full E. coli genome for analysis. A new advanced query page guides users in interactively constructing complex database queries against EcoCyc. A Macintosh version of EcoCyc is now available. A series of Webinars is available to instruct users in the use of EcoCyc.

Electronic Copies

DOI
10.1093/nar/gkn751

Adobe PDF

BibTeX

EndNote

Associated Projects

EcoCyc

EcoCyc: Encyclopedia of Escherichia coli Genes and Metabolism

EcoCyc is a bioinformatics database that describes the genome and the biochemical machinery of E. coli. The long-term goal of the project is to describe the molecular catalog of the E. coli cell, as well as the functions of each of its molecular parts, to facilitate a system-level understanding of E. coli.

AIC Personnel

Name Title E-mail
Karp, Peter D Director, Bioinformatics Research Group
Keseler, Ingrid M Senior Scientific Database Curator
Krummenacker, Markus Bioinformatics Scientist
Paley, Suzanne Computer Scientist
Shearer, Alexander Biologist

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