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Publication Details

Escherichia coli K-12: a cooperatively developed annotation snapshot – 2005

by Riley, M., and Abe, T., and Arnaud, M.B., and Berlyn, M.K.B., and Blattner, F.R., and Chaudhuri, R.R., and Glasner, J.D., and Horiuchi, T., and Keseler, I.M., and Kosuge, T., and Mori, H., and Perna, N.T., and Plunkett, G.3rd, and Rudd, K.E., and Serres, M.H., and Thomas, G.H., and Thomson, N.R., and Wishart, D., and Wanner, B.L.

Nucleic Acids Research, vol. 34, no. 1, pp. 1-9, 2006.

Abstract

The goal of this group project has been to coordinate and bring up-to-date information on all genes of Escherichia coli K-12. Annotation of the genome of an organism entails identification of genes, the boundaries of genes in terms of precise start and end sites, and description of the gene products. Known and predicted functions were assigned to each gene product on the basis of experimental evidence or sequence analysis. Since both kinds of evidence are constantly expanding, no annotation is complete at any moment in time. This is a snapshot analysis based on the most recent genome sequences of two E.coli K-12 bacteria. An accurate and up-to-date description of E.coli K-12 genes is of particular importance to the scientific community because experimentally determined properties of its gene products provide fundamental information for annotation of innumerable genes of other organisms. Availability of the complete genome sequence of two K-12 strains allows comparison of their genotypes and mutant status of alleles.

Electronic Copies

DOI
10.1093/nar/gkj405

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Associated Projects

EcoCyc

EcoCyc: Encyclopedia of Escherichia coli Genes and Metabolism

EcoCyc is a bioinformatics database that describes the genome and the biochemical machinery of E. coli. The long-term goal of the project is to describe the molecular catalog of the E. coli cell, as well as the functions of each of its molecular parts, to facilitate a system-level understanding of E. coli.

AIC Personnel

Name Title E-mail
Arnaud, Martha B. Alumnus
Keseler, Ingrid M Senior Scientific Database Curator

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