Current Projects

	BioCyc Database Collection The BioCyc Database Collection is a collection of Pathway/Genome Databases. Each database in the BioCyc collection describes the genome and metabolic pathways of a single organism.
	EcoCyc: Encyclopedia of Escherichia coli Genes and Metabolism EcoCyc is a bioinformatics database that describes the genome and the biochemical machinery of E. coli. The long-term goal of the project is to describe the molecular catalog of the E. coli cell, as well as the functions of each of its molecular parts, to facilitate a system-level understanding of E. coli.
	MetaCyc: Metabolic Pathway Database MetaCyc is a database of nonredundant, experimentally elucidated metabolic pathways. MetaCyc contains more than 1800 pathways from more than 2200 different organisms (circa 2012). The MetaCyc data were curated from more than 33,000 scientific publications. MetaCyc describes metabolic pathways, reactions, enzymes, and metabolites.
	Pathway Tools Pathway Tools is a systems biology software system that supports several use cases: Development of organism-specific database that integrate many bioinformatics datatypes, from genomes to pathways. Development of metabolic-flux models using flux-balance analysis. Scientific visualization, web publishing, and querying of organism-specific databases. Analysis of omics datasets. Computational prediction of metabolic pathways, metabolic pathway hole fillers, and operons. Comparative analyses.

Publications

The following are in reverse chronological order of publication.
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• Krieger, C. J. and Zhang, P and Mueller, L. A. and Wang, A. and Paley, S. and Arnaud, M. and Pick, J. and Rhee, S. Y. and Karp, P. D. MetaCyc: a multiorganism database of metabolic pathways and enzymes. Nucleic Acids Research, vol. 32, pp. D438-D442, 2004.  [Details]

• L. Olson, J. Pick, W. Ellis and P. Lim. A Chemical Assessment and HPLC Assay Validation of Bulk Paromomycin Sulfate. Journal of Pharmaceutical and Biomedical Analysis, vol. 15, p. 783, 1997.  [Details]

• J. Pick, L. Olson, W. Ellis and P. Lim. Development and validation of a method to extract and quantitate paromomycin and gentamicin from an Aquaphillic® cream formulation. Journal of Pharmaceutical and Biomedical Analysis, vol. 16, p. 131, 1997.  [Details]

• J. Pick, L. Olson, and P. Lim. Solubility and Solution Stability of WR272677, an Oral Anticyanide Candidate, in Proceedings of the 1993 Medical Defense Bioscience Review, vol. 2, p. 975, 1993.  [Details]